The show gave celebrity guests and the public the chance to have their say on the goings-on inside the Big Brother house.
For Big Brother 6, the show's name changed to Big Brother's Big Mouth.
Brand appeared in a sketch and performed stand-up at Amnesty International's Secret Policeman's Ball in 2006 In March 2007, he co-hosted an evening of the Teenage Cancer Trust gigs with Noel Fielding.
In December 2007, Brand performed for Queen Elizabeth II and Prince Philip as an act in the 2007 Royal Variety Performance.
In 2013, he released the successful stand-up special Messiah Complex.